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Statistics & Tracking
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15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Cay-14010) formed by 15-hydroxy PGDH. In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2). Formal Name: 9,15-dioxo-11alpha-hydroxy-prosta-5Z,13E-dien-1-oic acid. CAS Number: 26441-05-4. Synonyms: 15-keto PGE2. Molecular Formula: C20H30O5. Formula Weight: 350.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: >100 mg/ml (from PGE2), DMSO: >100 mg/ml (from PGE2), Ethanol: >100 mg/ml (from PGE2), PBS pH 7.2: >5 mg/ml (from PGE2). lambdamax: 229 nm. SMILES: O[C@H]1[C@H](/C=C/C(CCCCC)=O)[C@@H](C/C=C\CCCC(O)=O)C(C1)=O. InChi Code: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-17,19,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17-,19-/m1/s1. InChi Key: YRTJDWROBKPZNV-KMXMBPPJSA-N.