11alpha-Hydroxyprogesterone

11alpha-Hydroxyprogesterone (11alpha-OHP) is an inhibitor of 11beta-hydroxysteroid dehydrogenase (IC50s = 0.63 and 0.4 µM for recombinant human 11beta-HSD1 and 11beta-HSD2, respectively) and a derivative of the endogenous hormone progesterone (Cay-15876). 11alpha-OHP (10, 100, and 500 µg/animal) reduces urinary sodium excretion in male adrenalectomized rats when administered in combination with the steroid hormone corticosterone (Cay-16063) but not when administered alone. It potentiates corticosterone-induced increases in urinary potassium excretion in the same model but has no effect on urinary potassium excretion when administered alone. 11alpha-OHP increases blood pressure in rats when administered subcutaneously at a rate of 10 µg/hour, an effect that can be blocked by adrenalectomy or reduced by co-administration of the mineralocorticoid receptor antagonist RU-28318. It has been used as a precursor in the synthesis of various steroids, including 11beta-aminoprogesterone and derivatives of 11beta-aminoprogesterone and 5zeta-pregnanolone.Formal Name: 11alpha-hydroxy-pregn-4-ene-3,20-dione. CAS Number: 80-75-1. Synonyms: 11alpha-OHP, NSC 3350, U-0384. Molecular Formula: C21H30O3. Formula Weight: 330.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml, Ethanol: Sparingly Soluble: 1-10 mg/ml. SMILES: C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](C[C@H]3O)([C@H](CC4)C(C)=O)C. InChi Code: InChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17-,18+,19+,20-,21+/m0/s1. InChi Key: BFZHCUBIASXHPK-QJSKAATBSA-N.