ZZW-115

ZZW-115 is an inhibitor of nuclear protein 1 (NUPR1). It binds to NUPR1 (Kd = 2.1 µM) in a cell-free assay. ZZW-115 is cytotoxic against a panel of 11 pancreatic ductal adenocarcinoma cell lines (IC50s = 0.84-4.93 µM), as well as against a panel of 16 additional cancer cell lines, including glioblastoma, lymphoma, and leukemia cells (IC50s =0.25-7.75 µM). It induces apoptosis and necrosis in MiaPaCa-2, LIPC, Foie8b, 02-063, and HN14 pancreatic cancer cells when used at concentrations of 3 and 5 µM. ZZW-115 induces accumulation of reactive oxygen species (ROS), lipid peroxidation, and ferroptosis in MiaPaCa-2 cells in a concentration-dependent manner. It reduces tumor growth in a MiaPaCa-2 mouse xenograft model when administered at doses of 1, 2.5, or 5 mg/kg.Formal Name: N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanamine, trihydrochloride. CAS Number: 10122-45-9. Molecular Formula: C24H31F3N4S . 3HCl. Formula Weight: 574.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: soluble. lambdamax: 258 nm. SMILES: FC(F)(C1=CC=C2SC3=C(N(CCCN4CCN(CC4)CCN(C)C)C2=C1)C=CC=C3)F.Cl.Cl.Cl. InChi Code: InChI=1S/C24H31F3N4S.3ClH/c1-28(2)12-13-30-16-14-29(15-17-30)10-5-11-31-20-6-3-4-7-22(20)32-23-9-8-19(18-21(23)31)24(25,26)27,,,/h3-4,6-9,18H,5,10-17H2,1-2H3,3*1H. InChi Key: OBSKIDNFCBBXKJ-UHFFFAOYSA-N.