Zuclopenthixol

Zuclopenthixol is a dopamine receptor antagonist (Kis = 9.8 and 1.5 nM for D1 and D2 receptors, respectively). It also binds to serotonin (5-HT) receptor subtypes 5-HT2 and 5-HT6, alpha1-adrenergic, and histamine receptors (Kis = 7.6, 3, 33, and 169 nM, respectively) but not alpha2-adrenergic receptors (Ki = >4,300 nM). Zuclopenthixol inhibits dopamine-induced accumulation of cAMP in rat striatal homogenates (IC50 = 330 nM, Ki = 16 nM). It decreases stereotypic behavior induced by methylphenidate in mice (ED50 = 0.8 µmol/kg) and by apomorphine in rats and dogs (ED50s = 6.0 and 1.3 µmol/kg, respectively). Zuclopenthixol (0.7 and 1.4 mg/kg, i.p.) administered prior to testing enhances memory retrieval in rats in an inhibitory avoidance task without affecting locomotor activity.Formal Name: 4-[(3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazineethanol. CAS Number: 53772-83-1. Synonyms: Cisordinol, cis-Clopenthixol. Molecular Formula: C22H25ClN2OS. Formula Weight: 401.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 206, 232, 272 nm. SMILES: ClC1=CC2=C(C=C1)SC3=CC=CC=C3/C2=C/CCN4CCN(CCO)CC4. InChi Code: InChI=1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2/b18-5-. InChi Key: WFPIAZLQTJBIFN-DVZOWYKESA-N.