84 products were found matching "K04144"!

Dopamine is the predominant catecholamine neurotransmitter found in mammalian brain, where it controls a variety of functions including locomotor activity, cognition, emotion, positive reinforcement, food intake, and endocrine regulation. It also plays multiple roles in the periphery as a modulator of cardiovascular...

Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors). It depresses dopaminergic firing in paralyzed rats (ED50 = 2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 (Cay-15631). Pergolide (0.025 and 0.05 mg/kg)...

(-)-Apomorphine is a non-selective dopamine receptor agonist that exhibits pKi values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively. It produces biphasic effects on locomotor activity and displays anti-Parkinsonian and neuroprotective actions.Formal Name:...

SCH 23390 is a halobenzazepine that acts as a selective antagonist of the dopamine D1-like receptor subtypes D1 and D5 (Kis = 0.2 and 0.3 nM, respectively). In vivo studies have demonstrated that SCH 23390 can abolish pharmacologically-induced seizures. This compound is useful for studying the role of the dopamine...

(±)-SKF 81297 is a selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM). It demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic alpha2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively). Activation of dopamine D1-like receptors...

Zuclopenthixol is a dopamine receptor antagonist (Kis = 9.8 and 1.5 nM for D1 and D2 receptors, respectively). It also binds to serotonin (5-HT) receptor subtypes 5-HT2 and 5-HT6, alpha1-adrenergic, and histamine receptors (Kis = 7.6, 3, 33, and 169 nM, respectively) but not alpha2-adrenergic receptors (Ki = >4,300...

A-77636 is a dopamine D1 receptor agonist (Ki = 40 nM). It induces activity equal to or greater than dopamine (Cay-21992) in an adenylate cyclase assay of D1 receptor activity in fish retina and rat caudate putamen (EC50s = 7.4 and 1.1 nM, respectively) but does not show agonist activity at D2 receptors expressed in...

SCH 39166 is a dopamine D1 receptor antagonist (Ki = 5 nM). It is selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D5 receptors (Ki = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg). It reduces ethanol...

SKF 82958 is a dopamine D1 receptor agonist (K0.5 = 4 nM in a radioligand binding assay). It is selective for dopamine D1 over D2 receptors (K0.5 = 73 nM). SKF 82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50 = 491 nM). SKF 82958 (3 mg/kg) prevents and reverses...

SKF 83566 is a dopamine D1 receptor antagonist. In vivo, SKF 83566 (0.005, 0.01, and 0.03 mg/kg) reduces dexbenzetimide- and scopolamine-induced locomotor stereotypy in rats. It decreases ghrelin-induced increases in novel object exploration and food intake in rats when administered at a dose of 100 µg/kg. SKF 83566...

Description: ACEPROMAZINE MALEATE is a dopamine receptor antagonist. Target: Dopamine Receptor. Smiles: OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc2ccc(cc12)C(C)=O. References: Monteiro E R , Neto F J T , Castro V B , et al. Effects of acepromazine on the cardiovascular actions of dopamine in anesthetized dogs[J]....

Fluspirilene is a dopamine D2 and D3 receptor antagonist (Kis = 1.5 and 1.1 nM, respectively). It is selective for dopamine D2 and D3 receptors over dopamine D1, alpha1- and alpha2-adrenergic, H1 histamine, and sigma-1 (sigma1) receptors (Kis = 450, 102, >5,000, 540, and 150 nM, respectively), muscarinic...