ZD 4190

A VEGFR1, VEGFR2, and EGFR inhibitor (IC50s = 0.7, 0.03, and 0.4 µM, respectively), selective for these kinases over PDGFRbeta, FGFR1, and HER2 (IC50s = 3.4, >100, and >100 µM, respectively) and MEK, Cdk2, IGF-1R, Akt, and Tie2 (IC50s = >10, >10, >20, >20, and >100 µM, respectively), selectively inhibits VEGF- or EGF-induced proliferation of HUVECs over FGF-induced proliferation of HUVECs (IC50s = 0.05, 0.05, and 1.5 µM, respectively), reduces tumor volume in a Calu-6 NSCLC mouse xenograft model at 100 mg/kg, inhibits training-induced increases in collateral blood flow and white gastrocnemius muscle capillarity in exercise-trained rats. Formulation: A solid. InChI: InChI=1S/C19H16BrFN6O2/c1-28-17-9-13-16(10-18(17)29-7-6-27-5-4-24-26-27)22-11-23-19(13)25-15-3-2-12(20)8-14(15)21/h2-5,8-11H,6-7H2,1H3,(H,22,23,25). InChIKey: YBTGTVGEKMZEQX-UHFFFAOYSA-N. SMILES: FC1=CC(Br)=CC=C1NC2=NC=NC3=C2C=C(C(OCCN4C=CN=N4)=C3)OC