Z-VEID-AFC (trifluoroacetate salt)

Z-VEID-AFC is a fluorogenic substrate for caspase-6. Upon enzymatic cleavage by caspase-6, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify caspase-6 activity. AFC displays excitation/emission maxima of 400/505 nm, respectively.Formal Name: N-[(phenylmethoxy)carbonyl]-L-valyl-L-alpha-glutamyl-L-isoleucyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-alpha-asparagine, trifluoroacetate salt. Synonyms: Z-Val-Glu-Ile-Asp-AFC, Z-Val-Glu-Ile-Asp-7-amino-4-trifluormethylcoumarin. Molecular Formula: C38H44F3N5O12 . XCF3COOH. Formula Weight: 819.8. Purity: >95%. Emission: 505 nm. Excitation: 400 nm. Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml. SMILES: C[C@@H](CC)[C@@](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)C(C)C)=O)CCC(O)=O)=O)([H])C(N[C@@H](CC(O)=O)C(NC(C=C2O3)=CC=C2C(C(F)(F)F)=CC3=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C38H44F3N5O12.C2HF3O2/c1-5-20(4)32(36(55)44-26(17-29(49)50)34(53)42-22-11-12-23-24(38(39,40)41)16-30(51)58-27(23)15-22)45-33(52)25(13-14-28(47)48)43-35(54)31(19(2)3)46-37(56)57-18-21-9-7-6-8-10-21,3-2(4,5)1(6)7/h6-12,15-16,19-20,25-26,31-32H,5,13-14,17-18H2,1-4H3,(H,42,53)(H,43,54)(H,44,55)(H,45,52)(H,46,56)(H,47,48)(H,49,50),(H,6,7)/t20-,25-,26-,31-,32-,/m0./s1. InChi Key: WDOXVCCKMPILHW-IIWYFVKYSA-N.