YM-90709

YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC50 values of 1 and 0.57 µM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay. It inhibits IL-5-induced eosinophil survival (IC50 = 0.45 µM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED50s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED50 = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.Formal Name: 5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-benz[7,8]indolizino[2,3-b]quinoxaline. CAS Number: 163769-88-8. Molecular Formula: C22H21N3O2. Formula Weight: 359.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml. lambdamax: 229, 246, 282, 383 nm. SMILES: COC1=C(OC)C=C(C2=CC3=NC4=CC=CC=C4N=C3N2C(C)(C)C5)C5=C1. InChi Code: InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3. InChi Key: HIXSPVQXXDULHS-UHFFFAOYSA-N.