Xylometazoline (hydrochloride)

Xylometazoline is an alpha-adrenergic receptor (alpha-AR) agonist that binds to alpha1A-, alpha1B-, alpha1D-, alpha2A-, alpha2B-, and alpha2C-ARs in a radioligand binding assay (IC50s = 0.08, 0.56, 0.45, 0.98, 1.8, and 0.22 µM, respectively). It increases intracellular calcium levels in HEK293 cells transfected with human alpha2B-ARs (EC50 = 99 µM) but not other alpha-ARs. Xylometazoline is also an agonist of the serotonin (5-HT) receptor subtype 5-HT1 (Kis = 0.7 and 14 nM for the human 5-HT1D and 5-HT1B receptors, respectively). It inhibits forskolin-induced cAMP production in CHO Pro 5 cells expressing human 5-HT1D and 5-HT1B receptors by 62 and 49%, respectively, when used at a concentration of 1 µM. Xylometazoline (0.25 µg/ml) induces contraction of isolated dog nasal mucosal blood vessels and reduces nasal patency in dogs when administered topically or intravenously.Formal Name: 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1H-imidazole, monohydrochloride. CAS Number: 1218-35-5. Molecular Formula: C16H24N2 . HCl. Formula Weight: 280.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: 5 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1.Cl. InChi Code: InChI=1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15,/h8-9H,6-7,10H2,1-5H3,(H,17,18),1H. InChi Key: YGWFCQYETHJKNX-UHFFFAOYSA-N.