47 products were found matching "K04137"!

This is an all-inclusive cell-based luciferase reporter assay kit targeting the the Human Adrenoreceptor Alpha 1D (ADRA1D). INDIGO's ADRA1A reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the ADRA1D. In addition to ADRA1D Reporter Cells, this kit...

This is an all-inclusive cell-based luciferase reporter assay kit targeting the the Human Adrenoreceptor Alpha 1D (ADRA1D). INDIGO's ADRA1A reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the ADRA1D. In addition to ADRA1D Reporter Cells, this kit...

Midodrine-d6 is intended for use as an internal standard for the quantification of midodrine (Cay-17349) by GC- or LC-MS. Midodrine is a prodrug form of the alpha1-adrenergic receptor (alpha1-AR) agonist desglymidodrine. It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean...

(-)-Norepinephrine is the endogenous isomer of (±)-norepinephrine (Cay-35580) that acts as a neurotransmitter and hormone and is biosynthesized from dopamine by dopamine beta-hydroxylase. It is an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for alpha1, alpha2, and beta1 adrenoceptors,...

Acetylcholine is a neurotransmitter that binds to nicotinic and muscarinic acetylcholine receptors (AChRs) in the central and peripheral nervous systems. It mediates motor function at the neuromuscular junction but also has functions in the parasympathetic and sympathetic nervous systems. It is involved in learning...

Phentolamine is a reversible antagonist of alpha-adrenergic receptors, non-specifically binding all alpha1- and alpha2-adrenoceptors with nanomolar affinities. Formulations containing phentolamine have been used in the treatment of hypertensive emergencies, as well as chronic and emergent pain.Formal Name:...

Prazosin is an antagonist of alpha1-adrenergic receptors (alpha1-ARs). It selectively binds to alpha1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant alpha1A-, alpha1B-, and alpha1D-ARs, respectively, over alpha2-ARs (Kis = 340 and 3.7 nM in alpha2A-AR-expressing HT-29 cells and...

White solid. An alpha1-adrenergic antagonist. In addition, it has high affinity and selectivity for central 5-hydroxytryptamine binding sites and inhibits platelet aggregation.

A biogenic amine present in herbal products and citrus juices. It has antidepressant-like effects by stimulating alpha1-adrenoceptors in mice.

Risperidone (Cay-13629) is a benzisoxazole derivative used for treating schizophrenia, and also the psychotic, affective, or behavioral symptoms associated with other disorders. Methyl 5,6,7,8-tetradehydro risperidone is used as an internal standard used in the quantitative analysis of risperidone.Formal Name:...

Risperidone E-oxime is a potential impurity found in commercial preparations of risperidone. Risperidone (Cay-13629) is a longer-acting benzisoxazole derivative used for treating schizophrenia, and also the psychotic, affective, or behavioral symptoms associated with other disorders. This second-generation...

Tamsulosin is a potent antagonist of alpha1-adrenergic receptors (alpha1-ARs, Ki = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for alpha1-ARs over alpha2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on...