XCT790

XCT790 is an inverse agonist of estrogen-related receptor alpha (ERRalpha, IC50 = ~300-500 nM). It demonstrates 90-100% inhibition of ERRalpha constitutive activity and has no significant activity at related nuclear receptors at 10 µM. XCT790 associates with the ligand-binding domain of ERRalpha and blocks ERRalpha/PGC-1alpha-dependent signaling, suppressing the expression of monoamine oxidases A and B. XCT790 induces proteasomal degradation of ERRalpha and potentiates the degradation of the estrogen receptor ERalpha by fulvestrant (Cay-10011269).Formal Name: 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-2-propenamide. CAS Number: 725247-18-7. Molecular Formula: C23H13F9N4O3S. Formula Weight: 596.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12 mg/ml, DMF:PBS (pH7.2) (1:30): 0.03 mg/ml, DMSO: 3 mg/ml. lambdamax: 253, 370 nm. SMILES: COC1=CC(/C=C(C(NC2=NN=C(C(F)(F)F)S2)=O)\C#N)=CC=C1OCC3=C(C(F)(F)F)C=C(C(F)(F)F)C=C3. InChi Code: InChI=1S/C23H13F9N4O3S/c1-38-17-7-11(6-13(9-33)18(37)34-20-36-35-19(40-20)23(30,31)32)2-5-16(17)39-10-12-3-4-14(21(24,25)26)8-15(12)22(27,28)29/h2-8H,10H2,1H3,(H,34,36,37)/b13-6+. InChi Key: HQFNFOOGGLSBBT-AWNIVKPZSA-N.