Wortmannin

Wortmannin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010591-1 1 mg -

6 - 10 business days*

44.00€
Cay10010591-5 5 mg -

6 - 10 business days*

120.00€
Cay10010591-10 10 mg -

6 - 10 business days*

207.00€
 
By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse... more
Product information "Wortmannin"
By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from Drosophila, murine, and human differ in sensitivity to wortmannin (IC50s = 5, 50, 450 nM, respectively). Wortmannin also inhibits polo-like kinase 1 (IC50 = 24 nM) and polo-like kinase 3 (IC50 = 49 nM), as well as mTOR, DNA-PK, PI4K, MLCK, and p38 MAPK at 50 to 100 fold higher concentrations than that needed for PI3K inhibition. Formal Name: 11-(acetyloxy)-1S,6bR,7,8,9aS,10,11R,11bR-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione. CAS Number: 19545-26-7. Synonyms: KY 12420. Molecular Formula: C23H24O8. Formula Weight: 428.4. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 14 mg/ml, DMSO:PBS (pH 7.2)(1:8): 0.1 mg/ml, Ethanol: 0.15 mg/ml. lambdamax: 257, 292 nm. SMILES: COC[C@H]1OC(=O)c2coc3C(=O)C4=C([C@H](OC(=O)C)C[C@]5(C)C(=O)CCC45)[C@]1(C)c23. InChi Code: InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12?,13-,15-,22+,23+/m1/s1. InChi Key: QDLHCMPXEPAAMD-ZGSWIPFCSA-N.
Keywords: KY 12420, 11-(acetyloxy)-1S,6bR,7,8,9aS,10,11R,11bR-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione
Supplier: Cayman Chemical
Supplier-Nr: 10010591

Properties

Application: PI3K inhibitor
MW: 428.4 D
Formula: C23H24O8
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 19545-26-7| Find alternatives
KEGG ID : K00922 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H300, H310, H330
P Phrases: P260, P262, P264, P270, P271, P280, P284, P301+310, P302+352, P304+340, P310, P320, P321, P330, P361+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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