Wnt Agonist I

Wnt Agonist I is a cell-permeable activator of Wnt signaling that does not inhibit GSK3beta (IC50 > 60 µM). It induces nuclear accumulation of beta-catenin, increasing transcriptional activity driven by TCF (EC50 = 700 nM) and altering embryonic development. Wnt Agonist I is effective in vivo, decreasing tissue damage and improving renal function after ischemia-reperfusion in rats.Formal Name: N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine. CAS Number: 853220-52-7. Synonyms: BML-284. Molecular Formula: C19H18N4O3. Formula Weight: 350.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.14 mg/ml. lambdamax: 215, 294 nm. SMILES: COC1=CC=CC(C2=CC(NCC3=CC=C(OCO4)C4=C3)=NC(N)=N2)=C1. InChi Code: InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23). InChi Key: FABQUVYDAXWUQP-UHFFFAOYSA-N.