WNK-IN-11

WNK-IN-11
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay29676-5 5 mg -

6 - 10 business days*

67.00€
Cay29676-10 10 mg -

6 - 10 business days*

119.00€
Cay29676-25 25 mg -

6 - 10 business days*

260.00€
Cay29676-50 50 mg -

6 - 10 business days*

360.00€
 
WNK-IN-11 is an allosteric inhibitor of lysine-deficient protein kinase 1 (WNK1, IC50 = 4 nM). It... more
Product information "WNK-IN-11"
WNK-IN-11 is an allosteric inhibitor of lysine-deficient protein kinase 1 (WNK1, IC50 = 4 nM). It is 57- and 1000-fold selective for WNK1 over WNK2 and WNK4, respectively, as well as a panel of 400 kinases at 10 µM. It inhibits WNK1-mediated phosphorylation of the transcription factor OSR1 in HEK293 cells (EC50 = 0.352 µM).Formal Name: [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-methanone. CAS Number: 2123489-30-3. Molecular Formula: C21H21Cl2N5OS. Formula Weight: 462.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml, DMSO: 25 mg/ml, Ethanol: 3 mg/ml. lambdamax: 221, 259, 325 nm. SMILES: O=C(C1=CC(C2=CSC(NC)=N2)=NC=C1Cl)N3CCN(CC4=CC=C(Cl)C=C4)CC3. InChi Code: InChI=1S/C21H21Cl2N5OS/c1-24-21-26-19(13-30-21)18-10-16(17(23)11-25-18)20(29)28-8-6-27(7-9-28)12-14-2-4-15(22)5-3-14/h2-5,10-11,13H,6-9,12H2,1H3,(H,24,26). InChi Key: MVXAYIXYYOVALX-UHFFFAOYSA-N.
Keywords: [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-methanone
Supplier: Cayman Chemical
Supplier-Nr: 29676

Properties

Application: Allosteric WNK1 inhibitor
MW: 462.4 D
Formula: C21H21Cl2N5OS
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 2123489-30-3| Matching products
KEGG ID : K08867 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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