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Item number: TGM-T5456-100mg

Description: WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM). Target: Serine/threonin kinase. Smiles: CNc1nc(cs1)-c1cc(C(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c(Cl)cn1. References: Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase...

Keywords:	Allosteric WNK Kinase Inhibitor
Application:	Allosteric WNK1 inhibitor
CAS	2123489-30-3
MW:	462.4 D

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WNK-IN-11

Item number: Cay29676-5

WNK-IN-11 is an allosteric inhibitor of lysine-deficient protein kinase 1 (WNK1, IC50 = 4 nM). It is 57- and 1000-fold selective for WNK1 over WNK2 and WNK4, respectively, as well as a panel of 400 kinases at 10 µM. It inhibits WNK1-mediated phosphorylation of the transcription factor OSR1 in HEK293 cells (EC50 =...

Keywords:	[5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-methanone
Application:	Allosteric WNK1 inhibitor
CAS	2123489-30-3
MW:	462.4 D

From 67.00€ *

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