Wedelolactone

Wedelolactone is a natural coumestan originally isolated from plants used in herbal therapies. It inhibits NF-kappaB signaling at the level of IKK action, resulting in suppression of NF-kappaB-mediated gene expression at concentrations of 1-100 µM. Wedelolactone can also inhibit hepatitis C virus NS5B RNA-dependent RNA polymerase in vitro (IC50 = 36 µM), STAT1 dephosphorylation (50 µM), and EZH2-EED interactions (Kd = 2.8 µM). Prolonged incubation of HepG2 liver cells with wedelolactone alters lipid metabolism through increased expression of AMPK, PPARalpha, lipoprotein lipase, and low-density lipoprotein receptor.Formal Name: 1,8,9-trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one. CAS Number: 524-12-9. Synonyms: IKK Inhibitor II. Molecular Formula: C16H10O7. Formula Weight: 314.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL, Ethanol: 20 mg/mL. lambdamax: 253, 351 nm. SMILES: OC1=CC2=C(OC(C(C(O)=CC(OC)=C3)=C3O4)=C2C4=O)C=C1O. InChi Code: InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3. InChi Key: XQDCKJKKMFWXGB-UHFFFAOYSA-N.