88 products were found matching "K04467"!

NIK SMI1 is an inhibitor of NF-kappaB-inducing kinase (NIK, Ki = 0.23 nM). It inhibits NF-kappaB activation in a reporter assay using HEK293 cells (IC50 = 34 nM). NIK SMI1 inhibits B cell activating factor-induced survival of isolated mouse splenic B cells (IC50 = 373 nM).Formal Name:...

White to light green solid. Soluble in DMSO, ethanol or dichloromethane. Insoluble in water. Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines, At low concentrations acts as antioxidant reducing oxidative stress generated through the TCR signaling...

Wedelolactone is a natural coumestan originally isolated from plants used in herbal therapies. It inhibits NF-kappaB signaling at the level of IKK action, resulting in suppression of NF-kappaB-mediated gene expression at concentrations of 1-100 µM. Wedelolactone can also inhibit hepatitis C virus NS5B RNA-dependent...

Mycotoxin, Antibacterial (Gram-positive) and antifungal, Immunoregulator by degradation of IkappaB (Inhibitor of NF-kappaB) and regulation of the TNF-alpha (tumor necrosis factor-alpha) and MAPK (mitogen-activated protein kinase) signaling pathways. Isolated from Penicillium citreo-viride.

BMS 345541 is a cell permeable inhibitor of the IkappaB kinases IKKalpha and IKKbeta (IC50s = 4 and 0.3 µM). It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM. BMS 345541 inhibits signaling through nuclear factor-kappaB (NF-kappaB) both in cells and in vivo, showing...

Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of...

Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of...

Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of...

Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of...

Anti-IKKalpha Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with IKK? from Human, Mouse and New World Monkey based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-IKK? from other sources has not been determined. Protein function:...

Anti-IKK alpha Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Antibody has no cross response to IKKb or IKKg. Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory...

Anti-IKK alpha Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. This polyclonal antibody has no cross response to IKKb or IKKy. Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as...