VU29

VU29 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGluR5, Ki = 250 nM). It potentiates glutamate-induced calcium flux in primary rat cortical astrocytes (EC50 = 10. nM). VU29 (30 mg/kg) prevents ethanol-induced memory impairments in the novel object recognition test in rats. It also reverses ethanol-induced conditioned place preference in rats when administered at a dose of 10 mg/kg for ten days, an effect that can be reversed by MTEP (Cay-14961) or MK-801. InChI: InChI=1S/C22H16N4O3/c27-22(17-11-13-19(14-12-17)26(28)29)23-21-15-20(16-7-3-1-4-8-16)24-25(21)18-9-5-2-6-10-18/h1-15H,(H,23,27) InChIKey: KIALCSMRIHRFPL-UHFFFAOYSA-N SMILES: O=C(C1=CC=C([N+]([O-])=O)C=C1)NC2=CC(C3=CC=CC=C3)=NN2C4=CC=CC=C4