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Item number: Cay43928-1

VU29 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGluR5, Ki = 250 nM). It potentiates glutamate-induced calcium flux in primary rat cortical astrocytes (EC50 = 10. nM). VU29 (30 mg/kg) prevents ethanol-induced memory impairments in the novel object recognition test in rats. It also...

Keywords:	N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitro-benzamide
Application:	Positive allosteric mGluR5 modulator
CAS	890764-36-0
MW:	384.4 D

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VU-29

Item number: TGM-T23515-100mg

Description: VU-29 is a positive allosteric mGlu5 receptor modulator with an EC50 of 9 nM and a Ki of 244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes [EC50: rmGluR1/rmGluR2=557 nM/1.5 µM, hmGluR4=154 nM]. Target: GluR. Smiles:...

Keywords:	VU 29
CAS	890764-36-0
MW:	384.39 D

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