VU0810464
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A GIRK1/2 and GIRK1/4 activator, induces GIRK1/2 and GIRK1/4 activity in a thallium flux assay... more
Product information "VU0810464"
A GIRK1/2 and GIRK1/4 activator, induces GIRK1/2 and GIRK1/4 activity in a thallium flux assay using HEK293 cells expressing GIRK1 and GIRK2 or GIRK1 and GIRK4 (EC50s = 165 and 720 nM, respectively), reduces stress-induced hyperthermia at 10 and 30 mg/kg, i.p. in mice but does not affect the percentage of time spent or distance traveled in the open arms of the elevated plus maze in mice at 30 mg/kg. Formulation: A solid. InChI: InChI=1S/C18H21ClFN3O/c1-12-9-17(23(22-12)14-5-3-2-4-6-14)21-18(24)11-13-7-8-16(20)15(19)10-13/h7-10,14H,2-6,11H2,1H3,(H,21,24). InChIKey: HNJJARDABGKWSO-UHFFFAOYSA-N. SMILES: ClC1=CC(CC(NC2=CC(C)=NN2C3CCCCC3)=O)=CC=C1F
| Keywords: | 3-chloro-N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)-4-fluoro-benzeneacetamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43073 |
Properties
| Application: | GIRK1/2 / GIRK1/4 activator |
| MW: | 349.83 D |
| Formula: | C18H21ClFN3O |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2126040-21-7| Matching products |
| KEGG ID : | K04997 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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