VU0255035

VU0255035 is a competitive, orthosteric antagonist of the muscarinic M1 receptor (IC50 = 130 nM). It displays at least 75-fold selectivity for M1 over other muscarinic receptors, as well as a panel of receptors, ion channels, and transporters. VU0255035 is effective in cells and in vivo and brain penetrating, blocking pilocarpine-induced seizures without disrupting contextual fear conditioning in mice. VU0255035 is used to examine the role of the M1 receptor in diverse situations.Formal Name: N-[3-oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide. CAS Number: 1135243-19-4. Synonyms: ML-012. Molecular Formula: C18H20N6O3S2. Formula Weight: 432.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 40 mg/ml. SMILES: O=C(CCNS(C1=CC=CC2=NSN=C21)(=O)=O)N(CC3)CCN3C4=CC=NC=C4. InChi Code: InChI=1S/C18H20N6O3S2/c25-17(24-12-10-23(11-13-24)14-4-7-19-8-5-14)6-9-20-29(26,27)16-3-1-2-15-18(16)22-28-21-15/h1-5,7-8,20H,6,9-13H2. InChi Key: WXDHQWPQLKGANZ-UHFFFAOYSA-N.