VU0240551

VU0240551 is a K+/Cl- cotransporter 2 (KCC2) inhibitor (IC50 = 568 nM). It selectively inhibits KCC2 over Na+/K+/Cl- cotransporter 1 (NKCC1, IC50 = >50 µM) but does inhibit the activity of adenosine A1 and A3 receptors, as well as inhibits activity of L-type calcium channels at the benzothiazepine site and human ether-a-go-go-related gene (hERG) potassium channels by greater than 50% in a panel of 68 receptors, ion channels, and transporters at 10 µM. VU0240551 decreases potassium ion uptake by 70% in HEK293 cells expressing KCC2 when used at a concentration of 1 µM.Formal Name: N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide. CAS Number: 893990-34-6. Molecular Formula: C16H14N4OS2. Formula Weight: 342.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml, DMSO: 25 mg/ml, Ethanol: 2 mg/ml. lambdamax: 277 nm. SMILES: O=C(NC1=NC(C)=CS1)CSC(N=N2)=CC=C2C3=CC=CC=C3. InChi Code: InChI=1S/C16H14N4OS2/c1-11-9-23-16(17-11)18-14(21)10-22-15-8-7-13(19-20-15)12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,17,18,21). InChi Key: WJRWSLORVIHRNX-UHFFFAOYSA-N.