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Description: VU-29 is a positive allosteric mGlu5 receptor modulator with an EC50 of 9 nM and a Ki of 244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes [EC50: rmGluR1/rmGluR2=557 nM/1.5 µM, hmGluR4=154 nM]. Target: GluR. Smiles: N(C(=O)C1=CC=C(N(=O)=O)C=C1)C=2N(N=C(C2)C3=CC=CC=C3)C4=CC=CC=C4
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