Vismodegib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits... more
Product information "Vismodegib"
Description: Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 µM), ABCG2 (IC50: 1.4 µM). Target: ABC, Autophagy, Hedgehog/Smoothened. Smiles: ClC=1C(=CC(NC(=O)C2=C(Cl)C=C(S(C)(=O)=O)C=C2)=CC1)C3=CC=CC=N3. References: Scales SJ, et al. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009 Jun,30(6):303-12.
| Keywords: | RG 3616, GDC-0449, Erivedge |
| Supplier: | TargetMol |
| Supplier-Nr: | T2590 |
Properties
| Application: | Targets smoothened (SMO) |
| MW: | 421.3 D |
| Formula: | C19H14Cl2N2O3S |
Database Information
| CAS : | 879085-55-9| Matching products |
| KEGG ID : | K06226 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H361, H410, H303 |
| P Phrases: | P201, P202, P273, P280, P312, P391, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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