Vilazodone (hydrochloride)

Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50s = 0.2 and 0.5 nM, respectively). It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.Formal Name: 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide. CAS Number: 163521-08-2. Synonyms: EMD 68843, SB 659746A. Molecular Formula: C26H27N5O2 . HCl. Formula Weight: 478.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 241, 271 nm. SMILES: O=C(N)C(O1)=CC2=C1C=CC(N3CCN(CCCCC4=CNC5=C4C=C(C#N)C=C5)CC3)=C2.Cl. InChi Code: InChI=1S/C26H27N5O2.ClH/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32,/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32),1H. InChi Key: RPZBRGFNBNQSOP-UHFFFAOYSA-N.