Verrucarin A

Verrucarin A is a macrocyclic trichothecene that has been found in M. verrucaria and has diverse biological activities. It induces apoptosis and production of reactive oxygen species (ROS) in MDA-MB-231 and T47D breast cancer cells when used at concentrations ranging from 100 to 500 ng/ml. Verrucarin A enhances LPS-induced secretion of IL-1beta and IL-18 in macrophage-differentiated peripheral blood mononuclear cells (PBMCs). It inhibits the growth of the multidrug-resistant P. falciparum strain K1 (EC50 = 0.9 ng/ml). Verrucarin A is active against M. incognita root-knot nematodes (MIC = 1.88 µg/ml).CAS Number: 3148-09-2. Synonyms: Muconomycin A, NSC 126728, NSC 200736. Molecular Formula: C27H34O9. Formula Weight: 502.6. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O[C@@H]([C@H](C)CCOC1=O)C(OC[C@@]23[C@@]([C@]4(CO4)[C@]5([H])O[C@]2([H])C=C(C)CC3)(C)[C@](C5)([H])OC(/C=C/C=C/1)=O)=O. InChi Code: InChI=1S/C27H34O9/c1-16-8-10-26-14-33-24(31)23(30)17(2)9-11-32-21(28)6-4-5-7-22(29)36-18-13-20(35-19(26)12-16)27(15-34-27)25(18,26)3/h4-7,12,17-20,23,30H,8-11,13-15H2,1-3H3/b6-4+,7-5+/t17-,18-,19-,20-,23+,25-,26-,27+/m1/s1. InChi Key: NLUGUZJQJYVUHS-UZUWKDTNSA-N. Origin: Fungus/Myrothecium sp..