VCP171

VCP171 is a positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 µM in a kinetic assay measuring agonist dissociation).. It reduces AMPA receptor-mediated evoked excitatory postsynaptic currents (eEPSCs) in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 µM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 µM, respectively).Formal Name: [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-methanone. CAS Number: 1018830-99-3. Molecular Formula: C18H12F3NOS. Formula Weight: 347.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml, Ethanol: 10 mg/ml. lambdamax: 210, 241 nm. SMILES: NC1=C(C(C2=CC=CC=C2)=O)C(C3=CC(C(F)(F)F)=CC=C3)=CS1. InChi Code: InChI=1S/C18H12F3NOS/c19-18(20,21)13-8-4-7-12(9-13)14-10-24-17(22)15(14)16(23)11-5-2-1-3-6-11/h1-10H,22H2. InChi Key: HNHLVOBHWXLIGP-UHFFFAOYSA-N.