UNC9426

UNC9426 is an inhibitor of the TAM family kinase Tyro3 (IC50 = 2. nM). It is selective for Tyro3 over MerTK and Axl (IC50s = 580 and 190 nM, respectively) and 74 other kinases in a panel at 1 µM. UNC9426 (10 µM) reduces ADP- or collagen-induced platelet aggregation in isolated human platelet-rich plasma. It does not increase total bleeding time in mice after tail tip transection when administered at a dose of 10 mg/kg. UNC9426 also reduces the uptake of phosphatidylserine-coated microparticles, a model of apoptotic cells, by THP-1 macrophages in an efferocytosis assay in a concentration-dependent manner and reduces colony formation in NCI H1650 or H1975 non-small cell lung cancer (NSCLC) cells (EC50s = 170 and 197 nM, respectively). Formal Name: trans-4-[2-[[3,5-bis(trifluoromethyl)phenyl]amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol. CAS Number: 3051784-94-9. Molecular Formula: C32H34F6N6O. Formula Weight: 632.7. Purity: >98%. Formulation (Request formulation change): A solid. Solubility: DMSO: Soluble: >10 mg/ml Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: FC(F)(C1=CC(NC2=NC=C3C(C4=CC=C(CN5CCN(CC5)C)C=C4)=CN(C3=N2)[C@@H]6CC[C@H](CC6)O)=CC(C(F)(F)F)=C1)F. InChi Code: InChI=1S/C32H34F6N6O/c1-42-10-12-43(13-11-42)18-20-2-4-21(5-3-20)28-19-44(25-6-8-26(45)9-7-25)29-27(28)17-39-30(41-29)40-24-15-22(31(33,34)35)14-23(16-24)32(36,37)38/h2-5,14-17,19,25-26,45H,6-13,18H2,1H3,(H,39,40,41)/t25-,26-. InChi Key: CPWDPNAAVHWMCG-DIVCQZSQSA-N. Storage: -20°C. Stability: > 4 years.