60 products were found matching "K05116"!

UNC9426 is an inhibitor of the TAM family kinase Tyro3 (IC50 = 2. nM). It is selective for Tyro3 over MerTK and Axl (IC50s = 580 and 190 nM, respectively) and 74 other kinases in a panel at 1 µM. UNC9426 (10 µM) reduces ADP- or collagen-induced platelet aggregation in isolated human platelet-rich plasma. It does not...

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TYRO3 antibody detects TYRO3 protein tyrosine kinase, encoded by the TYRO3 gene on chromosome 15q15.1. TYRO3 antibody is widely applied in studies of receptor tyrosine kinase signaling, cell survival, and immune regulation. TYRO3 is part of...

Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces...

BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively. At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively). In cancer cells,...

Recombinant human TYRO3 (GenBank Accession No. NM_006293), a.a. 455-end with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

TYRO3 is a member of the TAM receptor kinases and plays an important role in cell proliferation/survival, adhesion/migration, and regulation of inflammatory cytokine release. Along with other members of this family, Axl and c-Mer (MERTK), TYRO3 is part of an emerging class of innate immune checkpoints participating...

Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces...

Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces...

Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces...

LDC-1267 is a TAM family kinase inhibitor (IC50s = 5, 8, and 29 nM for Mer, Tyro3, and Axl, respectively). It is selective for TAM family kinases over a panel of 456 kinases at 1 µM, but does inhibit Met, Aurora B, LCK, and Src (IC50s = 35, 36, 51, and 338 nM, respectively). It inhibits suppression of proliferation...

Recombinant human TYRO3 protein with C-terminal 6×His tag. TYRO3(Ala41-Ser428) 6×His tag, Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell...

Description: LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM). Target: TAM Receptor. Smiles: CCOc1cn(nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)-c1ccc(F)cc1C. References: Paolino M, et al. Nature. 2014, 507(7493), 508-512.