UK 383367

UK 383367 is a potent inhibitor of bone morphogenetic protein 1 (BMP1, IC50 = 44 nM). It is more than 200-fold selective for BMP1 over a panel of matrix metalloproteinases. UK 383367 is effective in a cell-based model of collagen deposition is very effective at penetrating human skin in vitro.Formal Name: (betaR)-3-(aminocarbonyl)-beta-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide. CAS Number: 348622-88-8. Molecular Formula: C15H24N4O4. Formula Weight: 324.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/mL, DMSO: 25 mg/mL, DMSO:PBS (pH 7.2)(1:5): 0.16 mg/mL, Ethanol: 16 mg/mL. SMILES: O=C(NO)C[C@@H](CCCC1CCCCC1)C2=NC(C(N)=O)=NO2. InChi Code: InChI=1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1. InChi Key: ARJCBSRIPGJMAD-LLVKDONJSA-N.