TX1-85-1

Item number	Size	Delivery time	Price
TGM-T17182-1mg	1 mg	7 - 10 business days*	63.00€
TGM-T17182-5mg	5 mg	7 - 10 business days*	128.00€
TGM-T17182-10mg	10 mg	7 - 10 business days*	228.00€
TGM-T17182-25mg	25 mg	7 - 10 business days*	387.00€
TGM-T17182-50mg	50 mg	7 - 10 business days*	571.00€

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Description: TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent... more

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Product information "TX1-85-1"

Description: TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. Target: EGFR. Smiles: CC(=O)N1CCN(CC1)C1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)c(NC(=O)C=C)c2)c2c(N)ncnc12. References: Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec,10(12):1006-12.

Supplier:	TargetMol
Supplier-Nr:	T17182

Properties

Application:	ErbB3 inhibitor
MW:	580.68 D
Formula:	C32H36N8O3

Database Information

CAS :	1603845-32-4\| Matching products
KEGG ID :	K04361 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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