TWS119

TWS119
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10011251-1 1 mg -

6 - 10 business days*

37.00€
Cay10011251-5 5 mg -

6 - 10 business days*

92.00€
Cay10011251-10 10 mg -

6 - 10 business days*

145.00€
Cay10011251-25 25 mg -

6 - 10 business days*

318.00€
 
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a... more
Product information "TWS119"
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a number of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including cell division, apoptosis, and inflammation. TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3beta with an IC50 value of 30 nM. At 400 nM, TWS119 induces neurogenesis in mouse embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation. Formal Name: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol. CAS Number: 601514-19-6. Molecular Formula: C18H14N4O2. Formula Weight: 318.3. Purity: >90%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 233, 311 nm. SMILES: Oc1cccc(c1)Oc1ncnc2[nH]c(cc12)c1cccc(N)c1. InChi Code: InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22). InChi Key: VPVLEBIVXZSOMQ-UHFFFAOYSA-N.
Keywords: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol
Supplier: Cayman Chemical
Supplier-Nr: 10011251

Properties

Application: GSK3beta inhibitor
MW: 318.3 D
Formula: C18H14N4O2
Purity: >90%
Format: Crystalline Solid

Database Information

CAS : 601514-19-6| Find alternatives
KEGG ID : K03083 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302
P Phrases: P264, P270, P301+310, P330, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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