Triflupromazine (hydrochloride)

Triflupromazine is a phenothiazine with diverse biological activities. It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 µM in a radioligand binding assay). Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 µM). It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 µM. Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 µg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 µg per animal. Formulations containing triflupromazine were previously used as antipsychotics.Formal Name: N,N-dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine, monohydrochloride. CAS Number: 1098-60-8. Synonyms: Siquil. Molecular Formula: C18H19F3N2S . HCl. Formula Weight: 388.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5mg/mL, DMSO: 3mg/mL, Ethanol: 5mg/mL, Ethanol:PBS (pH 7.2) (1:10): 0.09mg/mL. lambdamax: 259, 308 nm. SMILES: FC(F)(F)C1=CC=C2SC3=CC=CC=C3N(CCCN(C)C)C2=C1.Cl. InChi Code: InChI=1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21,/h3-4,6-9,12H,5,10-11H2,1-2H3,1H. InChi Key: FTNWXGFYRHWUKG-UHFFFAOYSA-N.