trans-Resveratrol

trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 µM, respectively) but not COX-2 (EC50s = >100 µM and 85 µM, respectively). trans-Resveratrol (200 µM) also activates sirtuin 1 (SIRT1), as well as inhibits a variety of targets including ERK1, JNK1, Src, PKCalpha, aromatase/CYP19, and DNA polymerases alpha and delta (IC50s = 37, 50, 20, in vitro. It inhibits free radical formation induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in HL-60 cells and reduces the tumor incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. Intravaginal administration of trans-resveratrol (12.5% v/v) inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication and delays the development of extravaginal disease in mouse models of vaginal HSV infection. It also prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.Formal Name: 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol. CAS Number: 501-36-0. Synonyms: (E)-Resveratrol. Molecular Formula: C14H12O3. Formula Weight: 228.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 100 mg/ml, DMSO: 50 mg/ml, EtOH: 50 mg/ml, PBS pH 7.2: 100 ug/ml. lambdamax: 218, 307, 321 nm. SMILES: Oc1ccc(cc1)\C=C/c1cc(O)cc(O)c1. InChi Code: InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+. InChi Key: LUKBXSAWLPMMSZ-OWOJBTEDSA-N.