Tranexamic Acid

Tranexamic acid is an inhibitor of fibrinolysis that inhibits the interaction of plasmin with fibrin (IC50 = 3.1 µM in isolated human plasma). It decreases alpha-naphthylisothiocyanate (ANIT)-induced increases in the expression of the profibrogenic genes Timp1 and Col1a1, but not Itgb6, Tgfbeta1, or Tgfbeta2, and reduces protein levels of cytokeratin 19 (CK19) and type I collagen in the liver after 28 days in a mouse model of chronic bile duct injury.Formal Name: trans-4-(aminomethyl)-cyclohexanecarboxylic acid. CAS Number: 1197-18-8. Synonyms: AMCA, TXA. Molecular Formula: C8H15NO2. Formula Weight: 157.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OC([C@@H]1CC[C@@H](CN)CC1)=O. InChi Code: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-. InChi Key: GYDJEQRTZSCIOI-LJGSYFOKSA-N.