Trametinib

Trametinib
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16292-25 25 mg -

6 - 10 business days*

92.00€
Cay16292-50 50 mg -

6 - 10 business days*

156.00€
Cay16292-100 100 mg -

6 - 10 business days*

181.00€
Cay16292-250 250 mg -

6 - 10 business days*

405.00€
 
Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation... more
Product information "Trametinib"
Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively). Trametinib inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM) and seven cell lines expressing mutant K-Ras (IC50s = 2.2-174 nM) but does not inhibit the growth of wild-type COLO 320DM cells expressing both B-RAF and K-Ras (IC50 = >10,000 nM). It reduces tumor growth in HT-29 and COLO 205 mouse xenograft models when used at doses of 0.3 and 1 mg/kg per day. Trametinib (0.03 and 0.1 mg/kg per day) also decreases M. tuberculosis-induced increases in hind paw volume in a rat model of arthritis. Formulations containing trametinib, in combination with dabrafenib, have been used in the treatment of metastatic mutant B-RAFV600E melanoma.Formal Name: N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-acetamide. CAS Number: 871700-17-3. Synonyms: GSK1120212, JTP-74057. Molecular Formula: C26H23FIN5O4. Formula Weight: 615.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 3 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 250, 330 nm. SMILES: CC(NC1=CC(N2C(C(C(N(C3CC3)C2=O)=O)=C(NC4=CC=C(I)C=C4F)N5C)=C(C)C5=O)=CC=C1)=O. InChi Code: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34). InChi Key: LIRYPHYGHXZJBZ-UHFFFAOYSA-N.
Keywords: GSK1120212, JTP-74057, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-acetamide
Supplier: Cayman Chemical
Supplier-Nr: 16292

Properties

Application: MEK1 / MEK2 inhibitor
MW: 615.4 D
Formula: C26H23FIN5O4
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 871700-17-3| Matching products
KEGG ID : K04368 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H317, H361, H372
P Phrases: P201, P202, P260, P261, P264, P270, P272, P280, P302+352, P308+313, P314, P321, P333+313, P362+364, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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