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GSK1120212
GSK1120212

Item number: LKT-G7440.5

GSK1120212 inhibits MEK1/2 and is currently in clinical trials as a potential treatment for melanoma. GSK1120212 exhibits anticancer chemotherapeutic activity, upregulating p27 expression and inhibiting growth in colorectal cancer cells and suppressing tumor growth in colorectal cancer xenografts.
Keywords: Trametinib, JTP-74057
Application: MEK1/2 inhibitor
CAS 871700-17-3
MW: 615.39 D
From 104.00€ *
Review
Trametinib
Trametinib

Item number: Cay16292-25

Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively). Trametinib inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM)...
Keywords: GSK1120212, JTP-74057,...
Application: MEK1 / MEK2 inhibitor
CAS 871700-17-3
MW: 615.4 D
From 92.00€ *
Review
GSK-1120212
GSK-1120212

Item number: SYN-1170-M010

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC(50) values of 0.92nM and 1.8nM respectively. Target: MEK1 - MEK2 , Kinase Group: STE , Substrate: Serine-Threonine
Keywords: JTP-74057, GSK212, Trametinib
Application: MEK1 / MEK2 inhibitor
CAS 871700-17-3
MW: 615,4 D
From 106.00€ *
Review