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GSK1120212
GSK1120212

Item number: LKT-G7440.5

GSK1120212 inhibits MEK1/2 and is currently in clinical trials as a potential treatment for melanoma. GSK1120212 exhibits anticancer chemotherapeutic activity, upregulating p27 expression and inhibiting growth in colorectal cancer cells and suppressing tumor growth in colorectal cancer xenografts.
Keywords: Trametinib, JTP-74057
Application: MEK1/2 inhibitor
CAS 871700-17-3
MW: 615.39 D
From 118.00€ *
Review
Trametinib
Trametinib

Item number: Cay16292-25

The dual specificity mitogen-activated protein kinase kinases (MEK) isoforms MEK1 and MEK2 function in a RAS/RAF/MEK/ERK signaling pathway to control cell growth, survival, and differentiation. Trametinib is a potent inhibitor of both MEK 1 and 2 that works in an ATP-noncompetitive fashion (IC50s = 0.7 and 0.9 nM,...
Keywords: GSK1120212, JTP-74057,...
Application: MEK1 / MEK2 inhibitor
CAS 871700-17-3
MW: 615.4 D
From 69.00€ *
Review
GSK-1120212
GSK-1120212

Item number: SYN-1170-M010

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC(50) values of 0.92nM and 1.8nM respectively. Target: MEK1 - MEK2 , Kinase Group: STE , Substrate: Serine-Threonine
Keywords: JTP-74057, GSK212, Trametinib
Application: MEK1 / MEK2 inhibitor
CAS 871700-17-3
MW: 615,4 D
From 106.00€ *
Review
Trametinib (GSK-1120212, JTP-74057, Mekinist, CAS 871700-17-3), 99%
Trametinib (GSK-1120212, JTP-74057, Mekinist, CAS...

Item number: LC-T-8123_100mg

Soluble in DMSO at 20 mg/mL with warming, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-10 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
Keywords: GSK1120212, JTP-74057,...
Application: MEK1 / MEK2 inhibitor
CAS 871700-17-3
MW: 615,39 D
From 71.00€ *
Review