Torcetrapib

Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP, IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively). It is selective for CETP over phospholipid transfer protein (PLTP), lecithin:cholesterol acyltransferase (LCAT), and hepatic and lipoprotein lipases at 10 µM. Torcetrapib (30 mg/kg) inhibits CETP activity and increases HDL cholesterol levels in serum from transgenic mice expressing human CETP and ApoA1. It increases mean arterial blood pressure in Zucker fa/fa diabetic rats when administered at doses of 60 and 200 mg/kg.Formal Name: 4S-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2R-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid, ethyl ester. CAS Number: 262352-17-0. Synonyms: CP 529,414, (-)-Torcetrapib. Molecular Formula: C26H25F9N2O4. Formula Weight: 600.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 251 nm. SMILES: O=C(OC)N(CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)[C@H]2C[C@@H](CC)N(C(OCC)=O)C3=CC=C(C(F)(F)F)C=C32. InChi Code: InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1. InChi Key: CMSGWTNRGKRWGS-NQIIRXRSSA-N.