Tizanidine (hydrochloride)

Tizanidine is an alpha2-adrenergic receptor (alpha2-AR) agonist. Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective alpha2-AR antagonist RX781094 but not the alpha1-AR antagonists prazosin (Cay-15023) and WB-4101. It acts as a muscle relaxant that inhibits alpha- and gamma-rigidity in rats, reflex muscle tone in rabbits, and the linguomandibular reflex in cats without sedative, hemodynamic, or neurochemical effects. Formulations containing tizanidine have been used in the treatment of spasticity. This product is also available as an analytical reference standard (Cay-38559).Formal Name: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine, monohydrochloride. CAS Number: 64461-82-1. Synonyms: DS 103-282. Molecular Formula: C9H8N5ClS . HCl. Formula Weight: 290.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.2 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 228, 319 nm. SMILES: ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1.Cl. InChi Code: InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9,/h1-2H,3-4H2,(H2,11,12,13),1H. InChi Key: ZWUKMNZJRDGCTQ-UHFFFAOYSA-N.