117 products were found matching "K04138"!

Description: ADRA2A-VLP Protein, Human, Recombinant (His) is expressed in HEK293 Cells with C-10xHis (This tag can be tested only under denaturing conditions). The accession number is P08913.

Chlorpromazine (CPZ) is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM). It is also an antagonist of histamine H1, alpha1a-, alpha2b-, and alpha2C-adrenergic, and M3...

ST 91 is an agonist of alpha2-adrenergic receptors (alpha2-ARs). It induces cAMP accumulation in HEK293 cells expressing alpha2A-, alpha2B-, or alpha2C-ARs (EC50s = 155, 371, and 851 nM, respectively). ST 91 (100 nM) inhibits isoproterenol-induced relaxation in phenylephrine-precontracted isolated rat mesenteric...

Medetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Ki = 1.08 nM). It is selective for alpha2-ARs over alpha1-ARs (Ki = 1,750 nM). Medetomidine induces sedation in dogs. Formulations containing medetomidine have been used as sedatives in veterinary medicine. This product is also available as an...

An internal standard for the quantification of dexmedetomidine by GC- or LC-MS

Rauwolscine is a natural alkaloid that acts as a selective and reversible alpha2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both alpha1- and alpha2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki...

(-)-Norepinephrine is the endogenous isomer of (±)-norepinephrine (Cay-35580) that acts as a neurotransmitter and hormone and is biosynthesized from dopamine by dopamine beta-hydroxylase. It is an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for alpha1, alpha2, and beta1 adrenoceptors,...

Clonidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Kis = 61.66, 69.18, and 134.9 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively). It stimulates [35S]GTPgammaS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for alpha2A-,...

A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1, Kis = 4.39 and 3.47 µM for the human receptor and guinea pig transporter, respectively). It decreases adenosine uptake by 80% in PC12 cells when used at a concentration of 61 µM and increases...

Xylazine is an agonist of alpha2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an alpha2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. The alpha 2A adrenergic receptor is a member of the G protein-coupled receptor superfamily which include three highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic...

Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to alpha2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of alpha1-adrenoceptors (Ki = 1.8 µM). Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic...