119 products were found matching "K04138"!

Recombinant CHO-K1 cells stably overexpress human adrenoceptor alpha 2A (ADRA2A) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.

ST 91 is an agonist of alpha2-adrenergic receptors (alpha2-ARs). It induces cAMP accumulation in HEK293 cells expressing alpha2A-, alpha2B-, or alpha2C-ARs (EC50s = 155, 371, and 851 nM, respectively). ST 91 (100 nM) inhibits isoproterenol-induced relaxation in phenylephrine-precontracted isolated rat mesenteric...

Chlorpromazine (CPZ) is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM). It is also an antagonist of histamine H1, alpha1a-, alpha2b-, and alpha2C-adrenergic, and M3...

An internal standard for the quantification of dexmedetomidine by GC- or LC-MS

Medetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Ki = 1.08 nM). It is selective for alpha2-ARs over alpha1-ARs (Ki = 1,750 nM). Medetomidine induces sedation in dogs. Formulations containing medetomidine have been used as sedatives in veterinary medicine. This product is also available as an...

Idazoxan is an antagonist of alpha2-adrenergic receptors (alpha2-ARs) and imidazoline I1 and I2 receptors (IC50s = 69, 66, and 61 nM, respectively). It selectively binds to alpha2A- and alpha2C-ARs over alpha2B-ARs (Kds = 67, 69, and 407 nM, respectively), as well as alpha2-ARs over alpha1-ARs (IC50s = 0. and 4,000...

Solulibility: DMSO: Sparingly Soluble: 1-10 mg/ml: Ethanol: Sparingly Soluble: 1-10 mg/ml.

Fendiline is an alpha2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects. Fendiline has recently been reported to inhibit K-Ras plasma membrane localization (IC50 = 9.64 µM), which prevents K-Ras signal transduction and...

Rauwolscine is a natural alkaloid that acts as a selective and reversible alpha2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both alpha1- and alpha2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki...

(-)-Norepinephrine is the endogenous isomer of (±)-norepinephrine (Cay-35580) that acts as a neurotransmitter and hormone and is biosynthesized from dopamine by dopamine beta-hydroxylase. It is an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for alpha1, alpha2, and beta1 adrenoceptors,...

Clonidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Kis = 61.66, 69.18, and 134.9 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively). It stimulates [35S]GTPgammaS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for alpha2A-,...

A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1, Kis = 4.39 and 3.47 µM for the human receptor and guinea pig transporter, respectively). It decreases adenosine uptake by 80% in PC12 cells when used at a concentration of 61 µM and increases...