Tioconazole

Tioconazole is an imidazole antifungal that inhibits the growth of various fungi, including C. albicans, C. neoformans, A. fumigatus, and T. rubrum (MICs = 4.7, 0.1, 5.7, and 0.5 µg/ml, respectively). It inhibits C-14 demethylation of sterols in a cell-free C. albicans homogenate (IC50 = 50-80 nM). Tioconazole (2% w/v cream) reduces the number of viable Candida cells recovered from the vagina in a mouse model of vaginal candidiasis. Formulations containing tioconazole have been used in the treatment of vaginal yeast infections.Formal Name: 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole. CAS Number: 65899-73-2. Synonyms: (±)-Tioconazole. Molecular Formula: C16H13Cl3N2OS. Formula Weight: 387.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMSO: 25 mg/mL, Ethanol: 33 mg/mL, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL. lambdamax: 221 nm. SMILES: ClC1=CC(Cl)=C(C(CN2C=CN=C2)OCC3=C(Cl)SC=C3)C=C1. InChi Code: InChI=1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2. InChi Key: QXHHHPZILQDDPS-UHFFFAOYSA-N.