Tianeptine Metabolite MC5 (sodium salt)

Tianeptine metabolite MC5 is an active metabolite of the atypical antidepressant tianeptine (Cay-17561). It is formed from tianeptine by beta-oxidation. Tianeptine metabolite MC5 selectively induces G protein activation in bioluminescence resonance energy transfer (BRET) assays using HEK293T cells expressing the human µ-opioid receptor (MOR) over the human delta-opioid receptor (DOR, EC50s = 0.454 and >100 µM, respectively). It decreases immobility in the forced swim test in wild-type mice, but not MOR knockout mice, indicating MOR-dependent antidepressant-like activity when administered at a dose of 30 mg/kg.Formal Name: 5-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]-pentanoic acid, monosodium salt. CAS Number: 115220-11-6. Molecular Formula: C19H20ClN2O4S . Na. Formula Weight: 430.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: Slightly soluble, DMSO: Slightly soluble, Methanol: Slightly soluble. SMILES: O=C(CCCCNC1C2=C(N(S(=O)(C3=CC(Cl)=CC=C31)=O)C)C=CC=C2)[O-].[Na+]. InChi Code: InChI=1S/C19H21ClN2O4S.Na/c1-22-16-7-3-2-6-14(16)19(21-11-5-4-8-18(23)24)15-10-9-13(20)12-17(15)27(22,25)26,/h2-3,6-7,9-10,12,19,21H,4-5,8,11H2,1H3,(H,23,24),/q,+1/p-1. InChi Key: GBYSEZGRQUELJJ-UHFFFAOYSA-M.