Thapsigargin

Thapsigargin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10522-1 1 mg -

1 - 10 business days

70.00€
Cay10522-5 5 mg -

1 - 10 business days

280.00€
Cay10522-10 10 mg -

1 - 10 business days

490.00€
 
In cells, sarco/endoplasmic calcium ATPases (SERCAs) transport free calcium into the sarcoplasmic... more
Product information "Thapsigargin"
In cells, sarco/endoplasmic calcium ATPases (SERCAs) transport free calcium into the sarcoplasmic and endoplasmic reticula, lowering intracellular calcium levels to stop signaling through this cation. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM). Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. In vivo, thapsigargin and related sesquiterpene lactones have anti-inflammatory and anti-cancer effects.
Keywords: (3S,3aS,4R,6R,7S,8R)-6-acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydro-1H-cyclopenta[e]azulen-7-yl octanoate
Supplier: Cayman Chemical
Supplier-Nr: 10522-1

Properties

Application: SERCA inhibitor
MW: 650.8 D
Formula: C34H50O12
Purity: >97%
Format: Crystalline Solid

Database Information

CAS : 67526-95-8| Search using CAS
KEGG ID : K05853 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H315, H319, H334, H335
P Phrases: P261, P264, P271, P280, P284, P312, P321, P302+P352, P304+P340, P304+P341, P305+P351+P338, P332+P313, P337+P313, P342+P311, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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