TH1020

TH1020 is an inhibitor of the protein-protein interaction between toll-like receptor 5 (TLR5) and flagellin. It binds to the TLR5 heterodimer interface to disrupt TLR5-flagellin tetramer formation and inhibits flagellin-induced TLR5 signaling in TLR5-overexpressing HEK cells (IC50 = 0.85 µM). TH1020 (0.37 µM) inhibits flagellin-induced, TLR5-mediated secretion of TNF-alpha in primary human peripheral blood mononuclear cells (PBMCs).Formal Name: 4-[[4-(phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine. CAS Number: 1841460-82-9. Molecular Formula: C23H15N7S2. Formula Weight: 453.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 1 mg/ml. lambdamax: 236, 267, 293 nm. SMILES: C1(C2=CC=NC=C2)=NN=C(SC3=C4C(C5=CC=CN=C5S4)=NC=N3)N1CC6=CC=CC=C6. InChi Code: InChI=1S/C23H15N7S2/c1-2-5-15(6-3-1)13-30-20(16-8-11-24-12-9-16)28-29-23(30)32-22-19-18(26-14-27-22)17-7-4-10-25-21(17)31-19/h1-12,14H,13H2. InChi Key: CBBXTGWSGPEJEE-UHFFFAOYSA-N.