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Item number: TGM-T8727-100mg

Description: TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 µm) and specificity. Target: Antibacterial, TLR. Smiles: C(c1ccccc1)n1c(Sc2ncnc3c4cccnc4sc23)nnc1-c1ccncc1. References: Lei Yan, et al. Pyrimidine Triazole Thioether Derivatives as...

Application:	TLR5-flagellin protein-protein interaction inhibitor
CAS	1841460-82-9
MW:	453.54 D

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TH1020

Item number: Cay33553-10

TH1020 is an inhibitor of the protein-protein interaction between toll-like receptor 5 (TLR5) and flagellin. It binds to the TLR5 heterodimer interface to disrupt TLR5-flagellin tetramer formation and inhibits flagellin-induced TLR5 signaling in TLR5-overexpressing HEK cells (IC50 = 0.85 µM). TH1020 (0.37 µM)...

Keywords:	4-[[4-(phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
Application:	TLR5-flagellin protein-protein interaction inhibitor
CAS	1841460-82-9
MW:	453.5 D

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