Tetrabenazine-d7

Tetrabenazine-d7 is intended for use as an internal standard for the quantification of tetrabenazine (Cay-20380) by GC- or LC-MS. Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay). It dose-dependently reduces levels of the monoamines norepinephrine (Cay-16673), dopamine (Cay-21992), and serotonin (5-HT, Cay-14332) in rat brain and has been used to induce depressive-like behavior in animal models. Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntington's disease. Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntington's disease.Formal Name: rel-1,3R,4,6,7,11bR-hexahydro-9,10-dimethoxy-3-(2-(methyl-d3)propyl-2,3,3,3-d4)-2H-benzo[a]quinolizin-2-one. CAS Number: 2701977-99-1. Synonyms: TBZ-d7. Molecular Formula: C19H20D7NO3. Formula Weight: 324.5. Purity: >99% (deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble. SMILES: O=C1[C@@H](CC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])CN2[C@@](C(C=C(OC)C(OC)=C3)=C3CC2)([H])C1. InChi Code: InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m0/s1/i1D3,2D3,12D. InChi Key: MKJIEFSOBYUXJB-QCSJFPTQSA-N.