Telotristat

Telotristat is a tryptophan hydroxylase 1 (TPH1) inhibitor (IC50 = 16 nM). Dietary administration of telotristat to pregnant and lactating mice decreases serotonin (5-HT, Cay-14332) levels in maternal serum and decreases the femoral bone volume to tissue volume ratio, trabecular number and thickness, and cortical tissue mineral density, as well as serum calcium levels, in pups.Formal Name: 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine. CAS Number: 1033805-28-5. Synonyms: LP778902. Molecular Formula: C25H22ClF3N6O3. Formula Weight: 546.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 246, 307 nm. SMILES: NC1=NC(C2=CC=C(C[C@H](N)C(O)=O)C=C2)=CC(O[C@H](C3=CC=C(Cl)C=C3N4C=CC(C)=N4)C(F)(F)F)=N1. InChi Code: InChI=1S/C25H22ClF3N6O3/c1-13-8-9-35(34-13)20-11-16(26)6-7-17(20)22(25(27,28)29)38-21-12-19(32-24(31)33-21)15-4-2-14(3-5-15)10-18(30)23(36)37/h2-9,11-12,18,22H,10,30H2,1H3,(H,36,37)(H2,31,32,33)/t18-,22+/m0/s1. InChi Key: NCLGDOBQAWBXRA-PGRDOPGGSA-N.