TCS 46b

An antagonist of NR1A/2B subunit-containing NMDA receptors (IC50 = 0.0053 µM), selective for NMDA receptors containing NR1A/2B subunits over NMDA receptors containing NR1A/2A and NR1A/2C subunits (IC50s = 35 and >100 µM, respectively), inhibits L-DOPA-induced contralateral rotations in a rat model of 6-OHDA-induced Parkinson's disease at 10 mg/kg, has been radiolabeled and used as an NR1A/2B-selective PET radiotracer. Formulation: A solid. InChI: InChI=1S/C22H23N3O/c26-22-23-20-9-8-18(16-21(20)24-22)7-4-12-25-13-10-19(11-14-25)15-17-5-2-1-3-6-17/h1-3,5-6,8-9,16,19H,10-15H2,(H2,23,24,26). InChIKey: JJEXWPHPFZLTCU-UHFFFAOYSA-N. SMILES: O=C1NC2=CC(C#CCN3CCC(CC3)CC4=CC=CC=C4)=CC=C2N1