TCN 237 (hydrochloride)

An NR2B subunit-containing NMDA receptor antagonist (Ki = 0.85 nM), selectively inhibits glutamate and glycine-induced currents in whole-cell patch-clamp assays using L-M(TK-) cells expressing NR2B subunit-containing NMDA receptors over L-M(TK-) cells expressing NR2A- or NR2D subunit-containing NMDA receptors and HEK293 cells expressing NR2C subunit-containing NMDA receptors, inhibits carrageenan-induced mechanical hyperalgesia in rats at 3 mg/kg. Formulation: A solid. InChI: InChI=1S/C20H22FN3O.2ClH/c21-17-4-2-1-3-15(17)11-14-7-9-24(10-8-14)13-20-22-18-6-5-16(25)12-19(18)23-20,,/h1-6,12,14,25H,7-11,13H2,(H,22,23),2*1H. InChIKey: JYUWGWCFJMDMND-UHFFFAOYSA-N. SMILES: FC1=CC=CC=C1CC2CCN(CC2)CC3=NC4=CC(O)=CC=C4N3.Cl.Cl