TC-S 7009
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: TC-S 7009 is a potent and selective HIF-2alpha inhibitor (Kd: 81 nM) with... more
Product information "TC-S 7009"
Description: TC-S 7009 is a potent and selective HIF-2alpha inhibitor (Kd: 81 nM) with significantly higher affinity for HIF-2alpha than HIF-1alpha (Kd >> 5µM). TC-S 7009 disrupts HIF-2alpha heterodimerization, reduces HIF-2alpha target gene expression, and diminishes DNA binding activity. Target: HIF. Smiles: [O-][N+](=O)c1c(Nc2cc(F)cc(Cl)c2)ccc2nonc12. References: Scheuermann TH, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013,9(4):271-276.
| Supplier: | TargetMol |
| Supplier-Nr: | T17009 |
Properties
| Application: | EPAS-1 PAS-B domain heterodimerization inhibitor |
| MW: | 308.65 D |
| Formula: | C12H6ClFN4O3 |
Database Information
| CAS : | 1422955-31-4| Matching products |
| KEGG ID : | K09095 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H413 |
| P Phrases: | P264, P270, P273, P301+310, P321, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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